PEG for LNPs Drug Delivery System

www.biochempeg.com
PEG Derivatives | PEG Raw Materials

Biopharma PEG offers a wide range of high-quality PEG raw materials and PEG derivatives for laboratory and scientific use.

Over 5000+ monodispersed and polydispersed PEG derivatives are available;
Multifunctional groups cover amino, azide, maleimides, thoil, phospholipids, fluorescein, etc;
Quality reports (LC/MS, NMR, and HPLC) for each product
From lab scale to large scale GMP production

mPEG-OH

CAS No. 9004-74-4
Research Area: PEG Raw Materials, Drug Delivery

mPEG-OH is one of the most common PEG raw materials for further derivatization to prepare other reactive functional groups on PEG. It has so far been used for various commercial PEGylated drugs, such as PEG-Interferon and PEG-GCSF.

mPEG-AA

Research Area: PEGylation, Drug Delivery

mPEG-AA is one type of linear monofunctional PEG acid reagent. There is a methylene (CH2) linkage between PEG and the COOH group. mPEG-AA is also called mPEG-CM, carboxyl methyl, is critical PEG material for PEGylated drug and LNP drug delivery system.

mPEG-N,N-Ditetradecylacetamide

CAS No. 1849616-42-7
Research Area: LNP for mRNA Vaccine delivery

Also known as ALC-0159, it is a PEG/lipid conjugate (i.e. PEGylated lipid). According to public information, it is one of the excipients of Pfizer's COVID-19 mRNA vaccine.

DSPE-PEG-Mannose

Research Area: LNP for mRNA Vaccine delivery

DSPE-PEG-Mannose is a phospholipid for drug delivery systems, especially for mRNA vaccine delivery. It is an active target material, which can be used as an antitumor drug carrier and a liposome for targeted delivery.

mPEG-DMG

CAS NO. 160743-62-4
Research Area: LNP for mRNA Vaccine delivery

mPEG-DMG is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles. It has been used in the development of lipid nanoparticles for the delivery of mRNA-based vaccines.

The effective components of the mRNA vaccine are all encapsulated in lipid nanoparticles (LNPs), which protect the mRNA from degradation and can also efficiently complete the intracellular delivery of mRNA. Lipid nanoparticles mainly contain four components: ionizable lipids, neutral auxiliary lipids, cholesterol, and PEGylated lipids. PEG can enhance the stability and life of LNPs. Biopharma PEG has scaled up the GMP manufacture of related PEG derivatives for LNPs

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