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PEG can be classified as Monodispersed PEG and Polydispersed PEG. Monodispersed PEG are pure compounds with precise PEG units and single molecular weight. In contrast, polydispersed PEG is a polymer mixture with an average molecular weight, such as 5K, 10K, etc.
At present, most of the PEG compounds supplied on the market are polydisperse PEGs, which can help increase drug half-life and lower clearance rates, thus lowering the required dosages.
As a worldwide leader of PEG molecules, Biopharma PEG offers a wide array of PEG linkers, including monodispersed PEG and polydispersed PEG to empower your advanced research.
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Biopharma PEG supplies linear methoxy & multi-arm PEG raw materials ( PEG hydroxyl or PEG alcohol) with high purity and low polydispersity. These PEG raw materials are suitable for activation into PEG derivatives.
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4ARM-PEG-OH
M.W.: 2K, 5K, 10K, 20K
Purity: ≥95%
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mPEG-OH
M.W.: 1K, 2K, 5K, 10K, 20K
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OH-PEG-OH
M.W.: 1K, 6K, 10K
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Polydisperse PEGs in LNP Systems
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Recently, polydisperse PEGs in PEGylated lipid nanoparticles (LNPs), such as mPEG2000-DSPE or mPEG2000-DMG, have gained international attention for their use in the COVID-19 mRNA vaccines. PEG lipids have been used extensively to improve circulation times for liposome encapsulated (LNP) drugs and reduce non-specific uptakes.
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mPEG-DMG
M.W.: 1K, 2K, 5K, 10K
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DSPE-PEG-Mannose
M.W.: 1K, 2K, 5K, 10K
Purity: ≥95%
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mPEG-N,N-Ditetradecylacetamide
M.W.: 2K, 3.4k, 5K, 10K
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