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See below for a daily digest of the latest Parkinson's Disease news & perspectives!

Life’s History Can Lead to a Strong Conductor

Sep 25, 2020 09:00 am | Dr. C

 

hallucinations, stormThe conductor is a mental construct that supports metacognitive processes while in a rested state. That means it is a nonjudgmental observer of the mind that is curious without causing harm. There are many benefits to having a strong conductor, but for me, the most beneficial is the “mind palace.” I use the “mind palace” […]

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Scientists Develop New System to Better Manage Medication Delivery

Sep 25, 2020 07:00 am | Diana Campelo Delgado

 

new delivery systemScientists have developed a new system that can provide a controlled and sustained release of parkinsonian medications, thus enabling better management of Parkinson’s disease. The mechanisms behind this delivery system were described in the study, “Multi-Drug-Loaded Microcapsules with Controlled Release for Management of Parkinson’s Disease,” published in the journal Small. Parkinson’s is characterized by the […]

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Seelos Therapeutics, Duke University Agree to Test SLS-004 in Parkinson’s Pre-Clinical Study

Sep 25, 2020 07:00 am | Forest Ray, PhD

 

SLS-004Seelos Therapeutics has signed an agreement with Duke University in North Carolina to conduct a pre-clinical study of SLS-004, one of its gene therapy candidates, as a treatment for Parkinson’s disease. The proof-of-concept study will seek to determine if the investigational therapy can prevent or delay Parkinson’s disease and also test its safety and effectiveness. If warranted, […]

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Simvastatin Fails to Slow Parkinson’s Progression, Trial Data Shows

Sep 24, 2020 07:00 am | Joana Carvalho, PhD

 

simvastatinSimvastatin, a widely-used cholesterol-lowering medication, failed to slow the progression of Parkinson’s disease, according to data from a Phase 2 trial. Based on these findings, it was decided that a future Phase 3 study assessing the safety and efficacy of simvastatin in these patients would not be justified. Data from the study, called PD-STAT (NCT02787590), […]

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$7.2M Grant Advances Work Into LRRK2 Protein’s Role in Parkinson’s

Sep 24, 2020 07:00 am | Diana Campelo Delgado

 

LRRK2 and diseaseThe Aligning Science Across Parkinson’s (ASAP) initiative has awarded a $7.2 million grant to a research team working to unravel the structure and biology of leucine-rich repeat kinase 2 (LRRK2), a protein linked to familial Parkinson’s disease. The three-year grant, issued by the Michael J. Fox Foundation (MJFF), was given to an international team led by researchers at […]

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Reduced Protein Synthesis May Be Early Indicator for Parkinson’s

Sep 23, 2020 07:00 am | Diana Campelo Delgado

 

deep brain stimulationReduced protein synthesis could serve as a biomarker to help diagnose Parkinson’s disease, even before motor symptoms appear, a recent study suggests. The study, “Protein synthesis is suppressed in sporadic and familial Parkinson’s disease by LRRK2,” was published in The FASEB Journal. The LRRK2 protein (leucine-rich repeat kinase 2), also known as dardarin, plays an important […]

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Age, Depression, Other Factors Linked to Fatigue Progression, Study Finds

Sep 23, 2020 07:00 am | Diana Campelo Delgado

 

fatigueFatigue increases over time in people with Parkinson’s disease and is associated with several factors, including sex, age, depression symptoms, and higher cognitive function, a study has found. The results of the longitudinal study, “Progression of fatigue in Parkinson’s disease – A nine-year follow-up,” were published in the European Journal of Neurology. Fatigue, or unrelenting exhaustion, is […]

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Cognitive Changes Are Most Challenging Symptom for Parkinson’s Care Partners, Research Reveals

Sep 22, 2020 08:00 am | Marisa Wexler

 

Cognitive changesCognitive changes in people with Parkinson’s disease pose a substantial challenge for their care partners, new research suggests. The findings were presented at the 2020 Congress of Parkinson’s Disease and Movement Disorders (held virtually due to the COVID-19 pandemic) by researchers from the Parkinson’s Foundation, in a poster titled, “The Care Partner Perspective: Most Challenging […]

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‘Is Parkinson’s Inherited?’ MJFF Webinar Focuses on Genetics, Diversity in Trials

Sep 22, 2020 07:00 am | Forest Ray, PhD

 

MJFF webinar, genetics, clinical trialsA new webinar titled “Is Parkinson’s Inherited?” — led by a research vice president at the Michael J. Fox Foundation (MJFF) — focused on the genetics and heritability of Parkinson’s disease and spoke to the need for greater diversity in clinical trials. The MJFF’s latest Third Thursday Webinar, moderated by Brian Fiske, PhD, senior vice president […]

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UK, Japan Research Groups Back Joint New Regenerative Medicine Projects

Sep 21, 2020 07:00 am | Mary Chapman

 

regenerative medicine projectsThe United Kingdom’s Medical Research Council (MRC) and the Japan Agency for Medical Research and Development (AMED) are collaborating to support eight new regenerative medicine projects seeking to develop therapies for disorders such as Parkinson’s disease (PD). The landmark £7 million (about $9 million) partnership will fund collaborative projects that focus on early stage development […]

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