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JDRF nPOD Newsletter for Investigators
Table of Contents:

Eisenbarth Award for Team Science
Important Investigator Shipping Update
OPO Workshop

Donor Group Update
Case Narratives
New Investigators & Recent Publications
Islet Pilot Project
Annual Meeting Update

The JDRF nPOD 7th Annual Scientific Meeting, scheduled for February 22-25, 2015
is now at capacity and there is a wait list to attend. Those that have been accepted for a poster or oral presentation, please turn in your registration form, if you haven't already.
George S. Eisenbarth nPOD Award for Team Science


nPOD is pleased to announce that Dr. Alberto Pugliese at the University of Miami has been awarded a three-year grant for a total of $3,300,000 for the George S. Eisenbarth nPOD Award for Team Science. This grant will be used to substantially expand the activities and science supported by JDRF.

Key areas of support include:
1. Enhancement of infrastructure and administrative operations for nPOD,
2. Support for existing and additional investigator working groups, and
3. Pilot studies for individual labs that fall outside of working groups.

Further information regarding this award will be forthcoming in the new year.

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Shipping Policy Update

nPOD has seen tremendous growth since it started with six investigators in 2006. Today we support nearly 150 projects, representing some 17 countries.  While extremely pleased with this expansion, our actual funding remains at a level when we were supporting 70 efforts. Our funding entity, JDRF, has requested we consider exploring ways of instilling what might be considered a “cost recovery” system for nPOD. 
 
As a result, effective January 2015, sample shipping from nPOD to our investigators will require investigators to provide a shipping account number (e.g., FedEx, other) for billing of those costs.  Soon, investigators will be contacted by our staff to secure this information.
 
The individual shipping cost may nor appear that much, yet the sum of the total distributions from nPOD to all investigators amounts to a significant number (i.e., over 300 shipments per year).
 
We appreciate our scientific partners' continued support for nPOD

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  OPO Workshop and Sharing with nPOD

October 22-24, twenty-five people from around the country came to Gainesville to learn about the nPOD research program. They discussed ways to improve process and more broadly increase donations to research within their own organizations.

Lab tours and research presentations from top diabetes researchers helped show how important each donation to research is to our team of scientists.

These recovery partners understand the critical need for human tissue from organ donors with type 1 diabetes. We also want our investigators to consider sharing with nPOD any tissue they may have from new onset cases, as a means to understand the science more fully. Please contact Jayne Moraski or Mingder Yang to discuss donations to nPOD's biorepository.


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Donor Groups

nPOD provides a list of donor groups available for approved investigators.  Please check back often to see if new cases have been added, especially in the "Other" category which includes unusual cases which might aid your research.


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Case Narratives 

We are excited to announce a new feature that will become available soon for all nPOD cases: case narratives.

In order to provide you with the most comprehensive clinical overview of nPOD donors, we have developed case narratives that will allow you to gather a better understanding of the clinical status of each donor prior to death.

We are starting with cases with type 1 diabetes. 
These narratives will be available upon request, and should be available on DataShare in the coming months. We hope they can provide the background information necessary for your research.
 
Please email nPOD if you are interested in reviewing these narratives.
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New Projects & Publications  


New Investigators: We want to welcome the following new investigators to the nPOD consortium:

  • Seung Kim with Harini Chakravarthy from Stanford University- Investigating islet alpha-to-beta cell conversion in Diabetes
  • Luc Teyton from the Scripps Research Institute- Analysis of Immunocytes in Human Islets of Type 1 Diabetes Patients
  • Edward Phelps with Jeffrey Hubbell and Steinunn Baekkeskov from École Polytechnique Fédérale de Lausanne- How does induction of ER-stress in pancreatic beta cells affect the processing and trafficking of beta cell autoantigens?

If you know other investigators that would like to become part of our project, we encourage them to Apply to Join nPOD.

Reminder:  If you have a publication that relies on nPOD tissues, we want to know about it! Please fill out the Abstract & Submission form on the nPOD website

New publications: Congratulations to our investigators for the following publications over the last few months.
Krogvold L, Edwin B, Buanes T, Frisk G, Skog O, Anagandula M, Korsgren O, Undlien D, Eike M, Richardson SJ, Leete P, Morgan NG, Oikarinen S, Oikarinen M, Laiho JE, Hyöty H, Ludvigsson J, Hanssen KF, Dahl-Jørgensen K. (2014) Detection of a low-grade enteroviral infection in the islets of Langerhans of living patients newly diagnosed with type 1 diabetes. Diabetes. 2014 Nov 24. pii: DB_141370. [Epub ahead of print]

Kulkarni RN, Stewart AF (2014) Summary of the keystone islet workshop (April 2014): the increasing demand for human islet availability in diabetes research. Diabetes. 2014 Dec; 63(12):3979-81. doi: 10.2337/db14-1303.

Atkinson, MA (2014) Losing a Grip on the Notion of β-Cell Specificity for Immune Responses in Type 1 Diabetes: Can We Handle the Truth? Diabetes. Nov;63(11):3572-4. doi: 10.2337/db14-1069.

Skyler, JS (2014) Characterizing subgroups of type 1 diabetes. Diabetes. Nov;63(11):3578-80. doi: 10.2337/db14-1160.

Subauste A, Gianani R, Chang AM, Plunkett C, Pietropaolo S, Zhang YJ, Barinas-Mitchell E, Kuller LH, Galecki A, Halter JB, Pietropaolo M. (2014) Islet Autoimmunity Identifies a Unique Pattern of Impaired Pancreatic Beta-Cell Function, Markedly Reduced Pancreatic Beta Cell Mass and Insulin Resistance in Clinically Diagnosed Type 2 Diabetes. PLoS One. 2014 Sep 16;9(9):e106537. doi: 10.1371/journal.pone.0106537. eCollection 2014.

Schneider DA, von Herrath, MG. (2014) Potential viral pathogenic mechanism in human type 1 diabetes. Diabetologia. Oct;57(10):2009-18. doi: 10.1007/s00125-014-3340-7. Epub 2014 Jul 30.

Tracy S, Smithee S, Alhazmi A, Chapman N. (2014) Coxsackievirus can persist in murine pancreas by deletion of 5′ terminal genomic sequences. J Med Virol. Aug 11. doi: 10.1002/jmv.24039. [Epub ahead of print]

Pugliese A, Vendrame F, Reijonen H, Atkinson MA, Campbell-Thompson M, Burke GW (2014) New Insight on Human Type 1 Diabetes Biology: nPOD and nPOD-Transplantation. Curr Diab Rep. Oct;14(10):530. doi: 10.1007/s11892-014-0530-0.

Zhao Z, Low YS, Armstrong NA, Hyoje Ryu J, Sun S, Arvanites AC, Hollister-Lock J, Shah NH, Weir GC, Annes JP. (2014) Repurposing cAMP-Modulating Medications to Promote β-Cell Replication. Molecular Endocrinology. Aug 1:me20141120. [Epub ahead of print]

Piran R, Lee S-H, Li C-R, Charbono A, Bradley L M, and Levine F. (2014) Pharmacological induction of pancreatic islet cell transdifferentiation: relevance to type I diabetes. Cell Death and Disease 5, e1357; doi:10.1038/cddis.2014.311. Published online 31 July 2014.

Rodriguez-Calvo T, Ekwall O, Amirian N, Zapardial-Gonzalo J, and von Herrath MG (2014) Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes. Diabetes. Published online before print June 19, 104. Diabetes, June 19, pii: DB_140549.

Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M, Kronenberg-Versteeg D, Bingley PJ, Todd JA, Guy C, Dunger DB, Powrie J, Willcox A, Foulis AK, Richardson SJ, de Rinaldis E, Morgan NG, Lorenc A, Peakman M. (2014) Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes. Diabetes. Jun 17. pii: DB_140365. [Epub ahead of print].

Marika Bogdani, Pamela Y. Johnson, Susan Potter-Perigo, Nadine Nagy, Anthony J. Day, Paul L. Bollyky, and Thomas N. Wight (2014) Hyaluronan and Hyaluronan Binding Proteins Accumulate in both Human Type 1 Diabetic Islets and Lymphoid Tissues and Associate with Inflammatory Cells in Insulitis. Diabetes Published online before print March 27, 2014, doi: 10.2337/db13-1658 Diabetes, March 27

Dotta F, Sebastiani G. (2014). Enteroviral infections and development of type 1 diabetes: The Brothers Karamazov within the CVBs. Diabetes. Feb;63(2):384-6. doi: 10.2337/db13-1441.

Pugliese A, Yang M, Kusmarteva I, Heiple T, Vendrame F, Wasserfall C, Rowe P, Moraski JM, Ball S, Jebson L, Schatz DA, Gianani R, Burke GW, Nierras C, Staeva T, Kaddis JS, Campbell-Thompson M, Atkinson MA. (2014) The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings. Pediatr Diabetes. Feb; 15(1):1-9.

Ye J, Vives-Pi M, Gillespie KM (2014) Maternal microchimerism: increased in the insulin positive compartment of type 1 diabetes pancreas but not in infiltrating immune cells or replicating islet cells. PLoS One. Jan 31;9(1):e86985. doi: 10.1371/journal.pone.0086985. eCollection 2014.

Richardson, S.J., Morgan, N.G., Foulis, A.K. (2014) Pancreatic Pathology in Type 1 Diabetes Mellitus. Endocrine Pathology. Feb 14 [Epub ahead of print]

Roep BO, Tree TI. (2014) Immune modulation in humans: implications for type 1 diabetes mellitus. Nat Rev Endocrinol. doi: 10.1038/nrendo.2014.2. [Epub ahead of print]

Engin F, Nguyen T, Yermalovich A, Hotamisligil GS. (2014) Aberrant islet unfolded protein response in type 2 diabetes. Sci Rep. doi: 10.1038/srep04054.

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  Islet Isolation Pilot Project


nPOD has created an islet isolation pilot program, headed by Dr. Clayton Mathews. The project hopes to determine how many islets we can recover from T1D cases with short duration and how these islets will perform in various assays.
 
Though the project is slated to start in a few select locations, the following activities are underway:

  1. An Islet Isolation committee has been formed.
  2. Isolation site has been identified and contract negotiation is underway.
  3. All the process and logistics SOPs are completed.
  4. Pilot test investigators have been identified, and each will report back on islet viability for different assays they will be performing.

Organ donors with type 1 diabetes of short duration are rare. When consent for research donation occurs, the nPOD team looks forward to starting the pilot program.

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Copyright © 2014 Network for Pancreatic Organ Donors with Diabetes (nPOD), All rights reserved.
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nPOD is a collaborative type 1 diabetes research project funded by JDRF. We support scientific investigators by providing, without cost, rare and difficult to obtain tissues beneficial to their research. nPOD currently supports over 90 type 1 diabetes-related scientific studies at institutions around the world. Our hope is that nPOD will prove a useful resource to the community of researchers dedicated to finding a cure for type 1 diabetes.  For more information, please go to www.jdrfnpod.org