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JDRF nPOD Newsletter for Recovery Partners. 

June 2014. Issue 21.

Welcome Back, Jayne!
[Jayne Moraski standing in front of St. Michaels in downtown Kiev. Barricades and the Ukrainian flag can be seen in the background.]

Here at nPOD we are very excited to announce that Jayne Moraski has returned to us after a once-in-a-lifetime adventure with her family!
See you at AOPO!
We will be at the 2014 AOPO Annual Meeting in Baltimore, MD. Come by the nPOD booth to say hello and enter the drawing to win an iPOD!
Want to learn more about diabetes?

We offer a variety of materials to help educate your staff about diabetes and the research we do at nPOD. In addition to handouts, we do live webinars that can be tailored to meet the needs of your group. Please contact us at nPOD@pathology.ufl.edu if you are interested in learning more.
THANK YOU!
A huge thanks to our OPO partners who make nPOD possible. With each donor, we take another step in our understanding of type 1 diabetes. nPOD works with the top diabetes researchers throughout the world, supplying tissues and facilitating collaborations, in order to maximize the information from each precious gift to research.


Several members of the T1D community, both patients and family members, have expressed their gratitude for the generosity of the donor families who consent for research in the form of thank you letters. Below is a letter from a mother who has 2 children with T1D. These letters  have been well received by the Donor Family Services departments at several OPOs, and are available for your use. Please contact us at
npod@pathology.ufl.edu if you would like to receive them.



Dear Donor Family Member,

It is with great appreciation that I write this letter. As a parent of two children with type one diabetes, I know the challenges they face, the determination with which they live, and the need to find a cure for this disease. We are so much closer to understanding the disease and thus closer to finding a cure because of your family member making this life-giving decision.

As you probably know, the research that has resulted from donations has been dramatic. Scientists are now able to use human tissue samples and therefore are able to make critical discoveries. Each of these will have an impact on how my children will receive treatment and remain healthy until a cure is found.

But it is not just about my children; it is about so many more people. The rate of diagnosis is increasing all over the world. Now, more than ever, we need to find out the cause of this disease and how to stop it. The precious samples provided through your unselfish generosity will make a difference. Scientists are collaborating, sometimes for the first time, to make new discoveries in how the disease progresses in humans.Your loved one helped make this possible.

Thank you cannot express the gratitude our family feels for this gift. Please know that the legacy of your loved one will continue through the work of scientists now, and all the research discoveries to be made in the coming years.

Sincerely,
Carol
Over the past few months we have had the opportunity to travel around the United States to take part in JDRF TypeOneNation events and talk with many T1D patients and families. We have really enjoyed meeting so many wonderful people who are as passionate about diabetes and research as we are! Many people we talked with wanted to know more about the latest research happening in T1D. In response to these requests, we developed the "Investigator Spotlight", a newsletter that highlights a different researcher each month and includes a list of the most recent publications related to diabetes written by nPOD affiliated investigators.

To see these Investigator Spotlights, click here.
nPOD Donor Criteria
Please call IIAM (1-800-486-4426) or nPOD (1-866-731-6585) when you have donors that meet the following criteria for nPOD:
 
  1. Type 1 Diabetes:
    1. Age ≤ 20 years old, any duration
    2. Any age, with duration ≤ 7 years
  2. Autoantibody positive (no diabetes): Age ≤ 30 years old with 1 or more autoantibodies to type 1 diabetes (GAD, IA-2, ZnT8)
  3. Transplant: Any donor with a history of type 1 diabetes who has received a pancreas or pancreas/kidney transplant
  4. Type 2 Diabetes: Age ≤ 60 years old on Incretin therapy ≥ 6 months
(Incretins: Byetta/Exenatide, Januvia/Sitagliptin, Galvus/Vildagliptin, Onglyza/Saxagliptin, Tradjenta/Linagliptin, Victoza/Liraglutide)
Recent Publications
Marika Bogdani, Pamela Y. Johnson, Susan Potter-Perigo, Nadine Nagy, Anthony J. Day, Paul L. Bollyky, and Thomas N. Wight. (2014). Hyaluronan and Hyaluronan Binding Proteins Accumulate in both Human Type 1 Diabetic Islets and Lymphoid Tissues and Associate with Inflammatory Cells in Insulitis. Diabetes published online before print March 27, 2014, doi: 10.2337/db13-1658 Diabetes March 27, 2014

Dotta F, Sebastiani G. (2014). Enteroviral infections and development of type 1 diabetes: The Brothers Karamazov within the CVBs. Diabetes. Feb;63(2):384-6. doi: 10.2337/db13-1441.

Pugliese A, Yang M, Kusmartseva I, Heiple T, Vendrame F, Wasserfall C, Rowe P, Moraski JM, Ball S, Jebson L, Schatz DA, Gianani R, Burje GW, Nierras C, Staeva T, Kaddis JS, Campbell-Thompson M, Atkinson MA. (2014) The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings. Pediatr Diabetes. Feb;15(1):1-9

Ye J, Vives-Pi M, Gillespie KM (2014) Maternal microchimersim: increased in the insulin positive compartment of type 1 diabetes pancreas but not in infiltrating immune cells or replicating islet cells. PLoS One. Jan 31;9(1):e86985. doi: 10.1371/journal.pone.0086985. eCollection 2014.

Richardson, S.J., Morgan, N.G., Foulis, A.K. (2014) Pancreatic Pathology in Type 1 Diabetes Mellitus. Endocrine Pathology. Feb 14 [Epub ahead of print]

Roep BO, Tree TI. (2014) Immune modulation in humans: implications for type 1 diabetes mellitus. Nat Rev Endocrinol. dio: 10.1038/nrendo.2014.2 [Epub ahead of print]

Engin F, Nguyen T, Yermalovich A, Hotamisligil GS. (2014) Aberrant islet unfolded protein response in type 2 diabetes. Sci Rep. doi: 10.1038/srep04054

Bonner-Weir S, In't Veld P, Weir G. (2014) Re-analysis of study of pancreatic effects of incretin therapy: Methodological deficiencies. Diabetes Obes Metab. doi: 10.1111/dom.12257. [Epub ahead of print]

Atkinson MA. (2014). Pancreatic biopsies in type 1 diabetes: revisiting the myth of Pandora's box. Diabetologia. DOI 10.1007/s00125-013-3159-7

Richardson, S.J., Leete, P., Dhayal, S., Russell, MA., Oikarinen, M., Laiho, J., Svedin, S., Lind, K., Rosenling, T., Chapman, N., Bone, A.J., Foulis, A.K., Frisk, G., Flödstrom-Tullberg, M., Hober, D., Hyoty, H., Pugliese, A., Morgan, N.G. (2014). Detection of enterovirus in islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén D Et al [letter]. Diabetologia 57 (3): 647-649

Atkinson MA, Eisenbarth GS, Michels AW. (2014) Type 1 diabetes. Lancet 383(9911):69-82. 10.1016/S0140-6736(13)60591-7.Epub 2013 Jul 26

Cheung SS, Ou D, Metzger DL, Meloche M, Ao Z, Ng SS, Owen D, Warnock GL. (2014) B7-H4 Expression in Normal and Diseased Human Islet Î² Cells. Pancreas 43(1):128-34. doi:10.1097/MPA.0b013e31829695d2

Richardson, S.J., Leete, P., Dhayal, S., Russell, MA., Oikarinen, M., Laiho, J., Svedin, S., Lind, K., Rosenling, T., Chapman, N., Bone, A.J., nPOD-V Consortium, Foulis, A.K., Frisk, G., Flodstrom-Tullberg, M., Hober, D., Hyoty, H., Morgan, N.G. (2014). Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas. Diabetologia 57(2): 392-401
Copyright © 2014 Network for Pancreatic Organ Donors with Diabetes (nPOD), All rights reserved.
Quarterly Newsletter

nPOD is a collaborative type 1 diabetes research project funded by JDRF. We support scientific investigators by providing, without cost, rare and difficult to obtain tissues beneficial to their research. nPOD currently supports over 120 type 1 diabetes-related scientific studies at institutions around the world. Our hope is that nPOD will prove a useful resource to the community of researchers dedicated to finding a cure for type 1 diabetes. For more information, please visit www.jdrfnpod.org


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