JDRF nPOD Newsletter. May 2014. Issue 20.
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JDRF nPOD Newsletter. May 2014. Issue 20.
2014 nPOD Annual Meeting Attendees.        
[Photo courtesy of Dr. Antonio Toniolo, M.D.]
The theme of the 2014 nPOD Annual Meeting was "The Science of Team Science". 127 nPOD investigators and staff gathered for a few days in Atlantic Beach, FL to discuss diabetes, present their latest research findings, form new collaborations, see alligators, and share a few laughs.

Dr. Martha Campbell-Thompson, Ph.D. D.V.M., was recognized for her contribution to nPOD as the Principal Investigator and Director of OPPC (2007-2013).

Dr. Ivan Gerling, Ph.D., received the nPOD Collaboration Award this year in recognition of his exceptional willingness to collaborate and share resources.
Exeter slides available in Online Pathology
The nPOD Online Pathology Database now contains scanned images from slides used at an insulitis workshop in Exeter, UK, November 2013. These slides were submitted by several of the meeting attendees and some date back to the 1930s. A synopsis of this meeting can be found in Diabetologia [Campbell-Thompson ML, Atkinson MA, Butler AE, et al. (2013) The diagnosis of insulitis in human type 1 diabetes. Diabetologia 56: 2541-2543]
Project Summary Updates... We need yours!


The nPOD website is currently being updated to include a brief synopsis for each project.

A huge thank you to those investigators that have turned in their project summary!! 

If you have not yet submitted your overview, please e-mail Dr. Mingder Yang with a brief summary (300 words) of your nPOD project.

For example project summaries, see Current nPOD Projects.

nPOD has made tissues from 2 retired cases, 6011 and 6014, available to investigators for assay validation and/or the generation of preliminary data. Reasonable amounts of material can be requested using the tissue request form.

These specimens are available to approved nPOD investigators and to those investigators who do not yet have a project approved by nPOD.

When requesting such tissues, please provide a short justification in addition to the tissue request form.

All investigators requesting specimens must provide their IRB approval letter or exemption status for the use of specimens from deceased donors.

If you have any questions, please contact nPOD OPPC Manager Dr. Irina Kusmartseva.
  New Projects!

The nPOD Tissue Prioritization Committee (TPC) has been very busy reviewing and approving new projects!

Please join us in congratulating these investigators on their newly approved nPOD projects.

"De-differentiation during progression of beta cell loss in type 1 diabetes"
- Dorene Markel, Matthias von Herrath, Christopher Rhodes, Jeffrey Bluestone, Mark Atkinson, Matthias Hebrok, Kevan Herold, Domenico Accili, Peter Arvan

"Disruption of Tolerance by ER-stress in Type 1 Diabetes"
- Jon Piganelli, Eddie James

"Linking IHC immune profiles of duodenum and pancreas in T1D"
- Thomas Pieber

"Insulin Interacting Proteins and Stress Markers in T1D"
- Pamela Itkin-Ansari, William Balch, Randal Kaufman

"Molecular Signatures of Islet Inflammation in Type 1 Diabetes"
- Nika Danial, Ulupi Jhala

"Beta-cell Death and Survival"
- Graeme Bell, Manami Hara

"Beta-cell stress signatures and infection in T1D islets"
- Rick Lloyd, Heikki Hyoty, Joe Petrosino, Ivan Gerling

"In-situ Gene Profiling and Identification of T1D Disease Mechanisms"
- Bruce Seligmann, Klaus Pechhold, Horacio Rilo

"Identifying and Validating Noncoding RNAs as Human Beta Cell-Specific Biomarkers" 
- Zhiguang Guo, Alex Rabinovitch, Romano Regazzi

"The immunogenicity of abnormal catabolites of insulin metabolism"
- Emil Unanue

"Imaging Pancreatic Beta-cells with PET Neuroimaging Agents"
- Gary Cline, Richard Carson

"Epigenetic regulation of beta-cell function and identity"
- John Andrew Pospisilik, Tess Tsai-Hsiu Lu

"T follicular helper (TFH) and regulatory (TFR) cells in T1D"
- Georgia Fousteri

"Genetics of nPOD"
- Grant Morahan, Stephen Rich, Pat Concannon

"Identification of Exosomal Biomarkers that Predict T1D Progression"
- Terry Strom, Thomas Thornley, Maria Koulmanda

"Targeting AID expressing B-lymphocytes as possible clinically applicable T1D intervention"
- David Serreza, Kevin Mills

"Investigate the molecular link between increased risk of diabetes among patients with psychiatric disorders"
- Dale Greiner, Rita Bortell
          nPOD Publication Policy
When you have a minute, be sure to review the nPOD Publication Policy. This document encompasses acknowledgement statements, governs the use of nPOD images in publications, explains how to identify nPOD samples in your work, and provides other guidelines related to presentations and publications.

For more information, please visit the Publication Policy and Publications list.
Please send us a note when you publish papers using nPOD samples. We love when you share the bragging rights with us.

Congratulations to the following nPOD investigators who have published since our February newsletter:
  • Marika Bogdani, Pamela Y. Johnson, Susan Potter-Perigo, Nadine Nagy, Anthony J. Day, Paul L. Bollyky, and Thomas N. Wight (2014) Hyaluronan and Hyaluronan Binding Proteins Accumulate in both Human Type 1 Diabetic Islets and Lymphoid Tissues and Associate with Inflammatory Cells in Insulitis. Diabetes Published online before print March 27, 2014, doi: 10.2337/db13-1658 Diabetes, March 27, 2014
  • Dotta F, Sebastiani G. (2014). Enteroviral infections and development of type 1 diabetes: The Brothers Karamazov within the CVBs. Diabetes. Feb;63(2):384-6. doi: 10.2337/db13-1441.
  • Pugliese A, Yang M, Kusmarteva I, Heiple T, Vendrame F, Wasserfall C, Rowe P, Moraski JM, Ball S, Jebson L, Schatz DA, Gianani R, Burke GW, Nierras C, Staeva T, Kaddis JS, Campbell-Thompson M, Atkinson MA. (2014) The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings. Pediatr Diabetes. Feb;15(1):1-9.
  • Ye J, Vives-Pi M, Gillespie KM (2014) Maternal microchimerism: increased in the insulin positive compartment of type 1 diabetes pancreas but not in infiltrating immune cells or replicating islet cells. PLoS One. Jan 31;9(1):e86985. doi: 10.1371/journal.pone.0086985. eCollection 2014.
  • Richardson, S.J., Morgan, N.G., Foulis, A.K. (2014) Pancreatic Pathology in Type 1 Diabetes Mellitus. Endocrine Pathology. Feb 14 [Epub ahead of print]
  • Roep BO, Tree TI. (2014) Immune modulation in humans: implications for type 1 diabetes mellitus. Nat Rev Endocrinol. doi: 10.1038/nrendo.2014.2. [Epub ahead of print] 
  • Engin F, Nguyen T, Yermalovich A, Hotamisligil GS. (2014) Aberrant islet unfolded protein response in type 2 diabetes. Sci Rep. doi: 10.1038/srep04054.
In response to interest from the T1D community, nPOD has developed a series of investigator interviews that allow the researchers to introduce themselves and their work. As we continue this exciting initiative, we will be asking for your participation. Be on the lookout for an investigator spotlight request!

Learn more about your colleagues, click here to see the Investigator Spotlight feature on the nPOD website.
Copyright © 2014 Network for Pancreatic Organ Donors with Diabetes (nPOD), All rights reserved.
JDRF nPOD Newsletter. May 2014. Issue 20.

nPOD is a collaborative type 1 diabetes research project funded by JDRF. We support scientific investigators by providing, without cost, rare and difficult to obtain tissues beneficial to their research. nPOD currently supports over 120 type 1 diabetes-related scientific studies at institutions around the world. Our hope is that nPOD will prove a useful resource to the community of researchers dedicated to finding a cure for type 1 diabetes. For more information, please visit

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