How Mutant Protein Drives Cellular Toxicity in Huntington’s Revealed in Study
Aug 17, 2017 12:02 pm | Alice Melão
Aggregates of mutant huntingtin protein have been associated with cellular toxicity in Huntington’s disease. Now researchers have discovered that isolated forms of mutated huntingtin are actually responsible for major molecular changes in cells that will drive toxicity. The study, “Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington’s disease pathways,” was […]
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