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See below for a daily digest of the latest Huntington's Disease news!

Researchers Identify Variant in MSH3 Gene Related to Huntington’s Progression

Jun 22, 2017 02:55 pm | Iqra Mumal

 

MSH3 gene variantResearchers have identified a variant in the gene MSH3 that is linked with Huntington’s disease (HD) progression. The study, “Identification of genetic variants associated with Huntington’s disease progression: a genome-wide association study,” was published in the journal The Lancet Neurology. TRACK-HD was a prospective and observational study which collected data such as imaging, cognitive characteristics, […]

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Inhibiting Enzyme Slows Huntington’s Progression in Mice and Lengthens Their Lives, Study Reports

Jun 20, 2017 08:09 am | Joe Pierce

 

Huntington's enzymeInhibiting the activity of an enzyme preserved the movement capabilities of mice with Huntington’s, slowed the progression of the disease and extended the animals’ lives, according to a study. The dSETDB1/ESET enzyme can disrupt a mechanism that controls normal gene expression, the researchers discovered. Alterations in that expression, along with other circumstances, can lead to […]

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Low Pyk2 Protein Levels May Contribute to Memory Deficits in Huntington’s Disease, Study Shows

Jun 15, 2017 09:06 am | Joana Fernandes, PhD

 

WAVE Life SciencesLow levels of a protein called Pyk2 may be associated with the development of Huntington’s disease, according to a new study. Researchers found that normalizing its levels in the hippocampus, the brain region responsible for learning and memory, rescues memory deficits. These findings were published in a study titled, “Pyk2 modulates hippocampal excitatory synapses and […]

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Researchers Propose NfL as New Blood Marker of Huntington’s Disease Onset, Progression

Jun 13, 2017 03:30 pm | Magdalena Kegel

 

NfL is a potential marker of Huntington’s disease.A factor called neurofilament light (NfL) may act as a biomarker of progression in Huntington’s disease, as blood levels of the molecule increase with more severe neurodegeneration. However, the factor also might offer a better means to predict disease onset in people carrying huntingtin mutations, as demonstrated in the study, which was published in The […]

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